RESEARCH FOCUS

Our laboratory investigates specialized survival strategies used by the embryo as it grows within the uterus. Central to the embryo's survival is the formation of an organ derived from the embryo called the placenta. This organ gains access to the maternal blood supply and facilitates the delivery of nutrients to the fetus. We study how early stem cells develop into the placenta. We have learned that the placenta is built in response to cues present in the maternal environment; and diseases of pregnancy, such as preeclampsia and intrauterine growth restriction, result when the embryo is not successful in its adaptations to the maternal environment. Inadequate in utero adaptive responses have potentially long-lasting impacts on adult health and disease.

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UPCOMING EVENTS

International Federation of Placenta Associations Annual Meeting
2021
Amsterdam, Netherlands
The 17th Annual Gilbert S. Greenwald Symposium
October 7-8, 2020
Kansas City, Missouri
Society for the Study of Reproduction Annual Meeting
August 4-7, 2021
St. Louis, Missouri
Society for Reproductive Investigation Annual Meeting
July 6 - 9, 2021
Boston, Massachusetts

RECENT UPDATES

Annual Meeting of the Society for the Study of Reproduction:

 

Regan L. Scott:  Recipient of a 2020 Lalor Foundation Merit Award and a Pre-doctoral Poster Award from the Society for the Study of Reproduction

 

Ayelen Moreno:  Recipient of a 2020 Lalor Foundation Merit Award and a Post-doctoral Platform Finalist from the Society for the Study of Reproduction

 

Ross P. McNally:  Recipient of a 2020 Lalor Foundation Merit Award and a Post-doctoral Poster Award from the Society for the Study of Reproduction

 

Marija Kuna:  Recipient of a 2020 Society for the Study of Reproduction Trainee Travel Award

 

Vinay Shukla:  Recipient of a 2020 Society for the Study of Reproduction Trainee Travel Award

 

 

Fellowships:

 

Ayelen Moreno:  Recipient of a Postdoctoral Fellowship from the Lalor Foundation, https://lalorfound.org/

 

Vinay Shukla:  Recipient of a K-INBRE Postdoctoral Fellowship Award, https://www.k-inbre.org/

 

 

Publications:

 

Poorly controlled diabetes mellitus alters placental structure, efficiency, and plasticity

Nteeba, J, Varberg, KM, Scott, RL, Simon, M, Iqbal, K, Soares, MJ.  BMJ Open Diabetes Research & Care. 2020; 8(1):e001243. 

PMID: 32595139 PMCID: PMC7322553

RECENT PUBLICATIONS

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Mar 2016

Rethinking progesterone regulation of female reproductive cyclicity

PNAS

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Nov 2016

HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia

PNAS

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Jan 2017

Natural killer-cell deficiency alters placental development in rats

Biology of Reproduction

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Dec 2017

Ex vivo Trophoblast-specific Genetic Manipulation Using Lentiviral Delivery.

Bio Protocol

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Jan 2018

Hypoxia signaling and placental adaptations

Methods in Molecular Biology

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Feb 2018

Hemochorial placentation- development, function, and adaptations

Biology of Reproduction