Our laboratory investigates specialized survival strategies used by the embryo as it grows within the uterus. Central to the embryo's survival is the formation of an organ derived from the embryo called the placenta. This organ gains access to the maternal blood supply and facilitates the delivery of nutrients to the fetus. We study how early stem cells develop into the placenta. We have learned that the placenta is built in response to cues present in the maternal environment; and diseases of pregnancy, such as preeclampsia and intrauterine growth restriction, result when the embryo is not successful in its adaptations to the maternal environment. Inadequate in utero adaptive responses have potentially long-lasting impacts on adult health and disease.
Society for the Study of Reproduction Annual Meeting
July 15-19, 2024
Society for Reproductive Investigation
March 12-16, 2024
Vancouver, British Columbia, Canada
Greenwald Symposium on Reproductive and Developmental Sciences
Kansas City, KS & MO
American Society for Reproductive Medicine
October 19-23, 2024
Esteban Dominguez was awarded the Best Poster - Postdoctorate at the 2023 U.S. DOHaD meeting.
Mikaela Simon was awarded an NIH F31 fellowship.
Ayelen Moreno won a poster award at the 2023 Greenwald Symposium
Savannah Speckhart won a Poster Award at the 2023 Greenwald Symposium
ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development