RESEARCH FOCUS

Our laboratory investigates specialized survival strategies used by the embryo as it grows within the uterus. Central to the embryo's survival is the formation of an organ derived from the embryo called the placenta. This organ gains access to the maternal blood supply and facilitates the delivery of nutrients to the fetus. We study how early stem cells develop into the placenta. We have learned that the placenta is built in response to cues present in the maternal environment; and diseases of pregnancy, such as preeclampsia and intrauterine growth restriction, result when the embryo is not successful in its adaptations to the maternal environment. Inadequate in utero adaptive responses have potentially long-lasting impacts on adult health and disease.

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UPCOMING EVENTS

IRPR Seminars in Development and the Pathogenesis of Disease
2019 Dates 
The 16th Annual Gilbert S. Greenwald Symposium
November 7-8, 2019
Society for the Study of Reproduction Annual Meeting
July 9-12, 2020
Ottawa, Ontario, Canada
Society for Reproductive Investigation Annual Meeting
March 10-14, 2020
Vancouver, BC, Canada

RECENT PUBLICATIONS

Mar 2016

Rethinking progesterone regulation of female reproductive cyclicity

PNAS

Nov 2016

HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia

PNAS

Jan 2017

Natural killer-cell deficiency alters placental development in rats

Biology of Reproduction

Dec 2017

Ex vivo Trophoblast-specific Genetic Manipulation Using Lentiviral Delivery.

Bio Protocol

Jan 2018

Hypoxia signaling and placental adaptations

Methods in Molecular Biology

Feb 2018

Hemochorial placentation- development, function, and adaptations

Biology of Reproduction

The Institute for Reproduction and Perinatal Research 

The University of Kansas Medical Center

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