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Our laboratory investigates specialized survival strategies used by the embryo as it grows within the uterus. Central to the embryo's survival is the formation of an organ derived from the embryo called the placenta. This organ gains access to the maternal blood supply and facilitates the delivery of nutrients to the fetus. We study how early stem cells develop into the placenta. We have learned that the placenta is built in response to cues present in the maternal environment; and diseases of pregnancy, such as preeclampsia and intrauterine growth restriction, result when the embryo is not successful in its adaptations to the maternal environment. Inadequate in utero adaptive responses have potentially long-lasting impacts on adult health and disease.

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Image by Julian Hochgesang


Society for the Study of Reproduction Annual Meeting
July 11-14, 2023
Ottawa, Canada
Society for Reproductive Investigation
March 21-25, 2023
Brisbane, Australia
Greenwald Symposium on Reproductive and Developmental Sciences
November 2-3, 2023

Kansas City, KS & MO
American Society for Reproductive Medicine
October 14-18, 2023

New Orleans, LA


SRI2022 Ayelen poster

Ayelen Moreno won an Award for Best New Investigator Poster Presentation - SRI 2022

Mikaela Simon gave an oral presentation at the 2021 SSR meeting.

SRI2022 Kaela poster

Kaela Varberg won an Award for Best New Investigator Poster Presentation - SRI 2022

Kuna_Marija Greenwald 2022

Marija Kuna was a 2022 Greenwald poster award winner.

Scott_Regan Greenwald 2022

Regan Scott was a 2022 Greenwald poster award winner.

Esteban SSR presentation

Esteban Dominguez won a 2021 SSR Trainee Travel Award

Vinay SSR poster

Vinay Shukla was selected to give an oral presentation at the 2022 SRI annual meeting

Khursheed Iqbal received an R21 grant for his project entitled "A new animal model for investigating the invasive trophoblast lineage"


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October 2021

Intersection of regulatory pathways controlling hemostasis and hemochorial placentation


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January 2021

ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development


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November 2020

Protective role of IL33 signaling in negative pregnancy outcomes associated with lipopolysaccharide exposure


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November 2021

Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway
in a Rat Model of Dioxin Exposure

Environmental Health Perspectives

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February 2021

SUV39H2 controls trophoblast

stem cell fate

BBA - General Subjects

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May 2020

Poorly controlled diabetes mellitus alters placental structure, efficiency, and plasticity

BMJ Open Diabetes Research & Care

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