Institute for Reproduction and Perinatal Research
The University of Kansas Medical Center, Kansas City, KS
RESEARCH FOCUS
Our laboratory investigates specialized survival strategies used by the embryo as it grows within the uterus. Central to the embryo's survival is the formation of an organ derived from the embryo called the placenta. This organ gains access to the maternal blood supply and facilitates the delivery of nutrients to the fetus. We study how early stem cells develop into the placenta. We have learned that the placenta is built in response to cues present in the maternal environment; and diseases of pregnancy, such as preeclampsia and intrauterine growth restriction, result when the embryo is not successful in its adaptations to the maternal environment. Inadequate in utero adaptive responses have potentially long-lasting impacts on adult health and disease.
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UPCOMING EVENTS
Society for the Study of Reproduction Annual Meeting
July 26-29, 2022
Spokane, Washington
Society for Reproductive Investigation
March 15-19, 2022
Denver, Colorado
Greenwald Symposium on Reproduction
Fall 2022
Kansas City, MO
American Society for Reproductive Medicine
October 22-26, 2022
Anaheim, California
RECENT UPDATES
We are saddened to by the passing of former postdoctoral fellow in the lab, Jackson Nteeba.
Annual Meeting of the Society for the Study of Reproduction:
Marija Kuna: First Place for the Post-Doctoral Platform Competition
Marija Kuna: Lalor Foundation Merit Award
Regan Scott: 2021 Society for the Study of Reproduction Trainee Travel Award
Esteban Dominguez: 2021 Society for the Study of Reproduction Trainee Travel Award
Ayelen Moreno: 2021 Society for the Study of Reproduction Trainee Travel Award
Funding:
Esteban Dominguez: Postdoctoral Fellowship from the Lalor Foundation, https://lalorfound.org/
Regan Scott: Predoctoral Fellowship from the NIH / NICHD.
Khursheed Iqbal: R21 research grant from the NIH.
RECENT PUBLICATIONS
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October 2021
Intersection of regulatory pathways controlling hemostasis and hemochorial placentation
PNAS
January 2021
ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development
PNAS
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November 2020
Protective role of IL33 signaling in negative pregnancy outcomes associated with lipopolysaccharide exposure
FASEB
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November 2021
Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway
in a Rat Model of Dioxin Exposure
Environmental Health Perspectives
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February 2021
SUV39H2 controls trophoblast
stem cell fate
BBA - General Subjects
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May 2020
Poorly controlled diabetes mellitus alters placental structure, efficiency, and plasticity
BMJ Open Diabetes Research & Care