RESEARCH FOCUS

Our laboratory investigates specialized survival strategies used by the embryo as it grows within the uterus. Central to the embryo's survival is the formation of an organ derived from the embryo called the placenta. This organ gains access to the maternal blood supply and facilitates the delivery of nutrients to the fetus. We study how early stem cells develop into the placenta. We have learned that the placenta is built in response to cues present in the maternal environment; and diseases of pregnancy, such as preeclampsia and intrauterine growth restriction, result when the embryo is not successful in its adaptations to the maternal environment. Inadequate in utero adaptive responses have potentially long-lasting impacts on adult health and disease.

d13.5 IL15KO 3 CK&Dapi 4x stitch(2)_edit
IMG_3666.jpg
KU_Bio_Med_center_t440.jpg
Image by Julian Hochgesang

UPCOMING EVENTS

Society for the Study of Reproduction Annual Meeting
July 26-29, 2022
Spokane, Washington
Society for Reproductive Investigation
March 15-19, 2022
Denver, Colorado
Greenwald Symposium on Reproduction
Fall 2022

Kansas City, MO
American Society for Reproductive Medicine
October 22-26, 2022

Anaheim, California

RECENT UPDATES

SRI2022 Ayelen poster

Ayelen Moreno won an Award for Best New Investigator Poster Presentation - SRI 2022

Mikaela Simon gave an oral presentation at the 2021 SSR meeting.

SRI2022 Kaela poster

Kaela Varberg won an Award for Best New Investigator Poster Presentation - SRI 2022

Marija SSR presentation

Marija Kuna took First Place for the 2021 SSR Post-doctoral Platform Competition

Regan SSR poster

Regan Scott won a 2021 SSR Trainee Travel Award and has been selected to give an oral presentation at the 2022 SRI meeting

Esteban SSR presentation

Esteban Dominguez won a 2021 SSR Trainee Travel Award

Vinay SSR poster

Vinay Shukla was selected to give an oral presentation at the 2022 SRI annual meeting

Khursheed Iqbal received an R21 grant for his project entitled "A new animal model for investigating the invasive trophoblast lineage"

RECENT PUBLICATIONS

Pubs Jan2022 (1).png

October 2021

Intersection of regulatory pathways controlling hemostasis and hemochorial placentation

PNAS

Screen Shot 2018-12-03 at 11.40.05 AM.pn

January 2021

ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development

PNAS

Pubs Jan2022 (3).png

November 2020

Protective role of IL33 signaling in negative pregnancy outcomes associated with lipopolysaccharide exposure

FASEB

Pubs Jan2022 (2).png
Pubs Jan2022 (4).png

November 2021

Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway
in a Rat Model of Dioxin Exposure

Environmental Health Perspectives

Pubs Jan2022 (5).png

February 2021

SUV39H2 controls trophoblast

stem cell fate

BBA - General Subjects

Pubs Jan2022 (6).png

May 2020

Poorly controlled diabetes mellitus alters placental structure, efficiency, and plasticity

BMJ Open Diabetes Research & Care