RESEARCH FOCUS

Our laboratory investigates specialized survival strategies used by the embryo as it grows within the uterus. Central to the embryo's survival is the formation of an organ derived from the embryo called the placenta. This organ gains access to the maternal blood supply and facilitates the delivery of nutrients to the fetus. We study how early stem cells develop into the placenta. We have learned that the placenta is built in response to cues present in the maternal environment; and diseases of pregnancy, such as preeclampsia and intrauterine growth restriction, result when the embryo is not successful in its adaptations to the maternal environment. Inadequate in utero adaptive responses have potentially long-lasting impacts on adult health and disease.

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UPCOMING EVENTS

Society for the Study of Reproduction Annual Meeting
July 26-29, 2022
Spokane, Washington
Society for Reproductive Investigation
March 15-19, 2022
Denver, Colorado
Greenwald Symposium on Reproduction
Fall 2022

Kansas City, MO
American Society for Reproductive Medicine
October 22-26, 2022

Anaheim, California

RECENT UPDATES

We are saddened to by the passing of former postdoctoral fellow in the lab, Jackson Nteeba.

Annual Meeting of the Society for the Study of Reproduction:

 

Marija Kuna: First Place for the Post-Doctoral Platform Competition

Marija Kuna: Lalor Foundation Merit Award

 

Regan Scott: 2021 Society for the Study of Reproduction Trainee Travel Award

 

Esteban Dominguez: 2021 Society for the Study of Reproduction Trainee Travel Award

 

Ayelen Moreno: 2021 Society for the Study of Reproduction Trainee Travel Award

Funding:

 

Esteban Dominguez: Postdoctoral Fellowship from the Lalor Foundation, https://lalorfound.org/

 

Regan Scott: Predoctoral Fellowship from the NIH / NICHD.

Khursheed Iqbal: R21 research grant from the NIH.

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RECENT PUBLICATIONS

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October 2021

Intersection of regulatory pathways controlling hemostasis and hemochorial placentation

PNAS

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January 2021

ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development

PNAS

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November 2020

Protective role of IL33 signaling in negative pregnancy outcomes associated with lipopolysaccharide exposure

FASEB

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November 2021

Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway
in a Rat Model of Dioxin Exposure

Environmental Health Perspectives

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February 2021

SUV39H2 controls trophoblast

stem cell fate

BBA - General Subjects

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May 2020

Poorly controlled diabetes mellitus alters placental structure, efficiency, and plasticity

BMJ Open Diabetes Research & Care